Description
A Dynamic Indole Compound
Indole-3-Carbinol (I3C) is a well-characterized compound studied for its role in hormone-related pathways and metabolic processes. While I3C is associated with compounds found in cruciferous vegetables, this product utilizes a high-purity, precision-crafted form designed for consistency, stability, and controlled dosing.
Once ingested, I3C is converted in the stomach and gut into a range of bioactive metabolites, including diindolylmethane (DIM), indolocarbazole (ICZ), ascorbigen, and other indole derivatives. This conversion process has led to ongoing scientific interest in its role in supporting normal physiological and biochemical balance.
Why Choose Indole-3-Carbinol (I3C)?
- High-purity I3C designed for consistent potency
- Converts into multiple biologically active indole metabolites
- Studied for its role in hormone metabolism and cellular processes
- Suitable for both men’s and women’s wellness routines
- Commonly used in wellness strategies focused on metabolic and cellular balance
Why Choose TheraNaturals® Indole-3-Carbinol (I3C)?
TheraNaturals® was among the first to introduce Indole-3-Carbinol (I3C) to the supplement marketplace, helping bring awareness to this unique class of compounds now widely recognized as dietary indoles.
This legacy of early adoption reflects a long-standing commitment to science-based formulation, ingredient transparency, and product integrity.
Over time, TheraNaturals® has helped establish high-quality manufacturing benchmarks for I3C, emphasizing purity, consistency, and controlled production standards that support reliable product performance.
Key advantages of TheraNaturals® I3C include:
- High-purity, precision-crafted I3C for consistency and controlled potency
- Produced using advanced manufacturing standards designed to support quality and reproducibility
- Formulated to support predictable conversion into active indole metabolites
- Manufactured without unnecessary fillers, additives, or excipients
- Designed for long-term, consistent use within wellness routines
As interest in dietary indoles has grown, TheraNaturals® continues to emphasize clean formulation standards and scientifically informed product development, maintaining its position as an early innovator in this category.
What Are Dietary Indoles?
Dietary indoles are a class of compounds commonly associated with cruciferous vegetables. These compounds are studied for their unique biochemical interactions and involvement in supporting normal physiological balance.
The term “Dietary Indoles” has been widely used to describe this category of compounds and their role in nutrition and wellness.
How I3C Works in the Body
I3C acts as a precursor compound, forming multiple metabolites after ingestion. These derivatives are studied for their involvement in:
- Hormone metabolism pathways
- Cellular signaling processes
- Nutrient metabolism and methylation-related activity
- General biochemical balance
This multi-pathway activity contributes to its ongoing research across several areas of nutritional science.
Primary Areas of Nutritional Interest
Indole-3-Carbinol is commonly included in wellness routines focused on:
- Hormone metabolism and balance
- Men’s and women’s health support
- Breast and prostate wellness routines
- Estrogen metabolism support
- Methylation and nutrient metabolism
- General cellular and metabolic balance
Secondary Areas of Scientific Interest
I3C has also been explored in research settings related to:
- Cervical and reproductive tissue wellness
- Male wellness and fitness-related hormone balance
- Thyroid and adrenal-related physiological processes
- Lifestyle and environmental exposure response pathways
- Papillomavirus-related research interest
These areas reflect ongoing scientific investigation into indole compounds and their role in supporting normal physiological processes.
Suggested Use
Take 3–4 capsules daily, or as directed by a qualified healthcare professional.
For best results:
- Use consistently over time
- Take with meals to support tolerance
- If sensitivity occurs, divide doses throughout the day
Storage & Stability
- Store in a cool, dry place
- Keep away from heat, light, and moisture
- Amber bottle helps protect from light exposure
- Shelf life is typically 3–5 years when stored properly
Note:
A naturally strong aroma may be present and can vary slightly between batches.
When to Use / When Not to Use
When to Consider Use
Indole-3-Carbinol may be considered as part of a wellness routine focused on:
- Supporting normal hormone metabolism
- Maintaining metabolic and cellular balance
- Complementing nutrition strategies for men’s and women’s health
- Supporting overall wellness as part of a balanced lifestyle
When Not to Use (Important Considerations)
- Consult a healthcare provider prior to use if you are pregnant or lactating
- Not recommended for individuals undergoing chemotherapy or radiation therapy unless directed by a qualified healthcare professional
- Individuals with medical conditions or those taking medications should seek professional guidance prior to use
Additional Product Notes
- High-purity, precision-crafted compound
- Designed for consistency and stability
- Intended for consistent, long-term nutritional use
Other Names
3-Hydroxymethyl Indole, 3 Hydroxymethyl Indole, I3C, Indole 3 Carbinol,
3-(hydroxymethyl), 3-(hydroxyméthyl), 3 (hydroxymethyl) Indole,
3-Indolylcarbinol, 3 Indolylcarbinol, 3-Indolylmethanol, 3 Indolylmethanol,
Indol-3-Carbinol, Indole, Indole 3 Carbinol, Indole-3-methanol, Indole-3-méthanol
Supplement Disclaimer
This product is intended for supplemental use only. Use only as directed.
† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.





Helena Patterson –
Ms.
What are the side effects?
M Parish –
Side effects are generally related to gas or bloating. To mitigate this, you simple split up your dosing throughout the day and take with food.
Judy –
Judy
Dr. Bell recommended I take two a day a I have had cervical cancer previously and my paps and other procedures have not come back normal…I am hoping by taking this it will at least not get worse…my only complaint is this along with many of my other medications add up pricewise… but what does one do??
Renee Duncan –
A life saver
The I3C caps have worked a miracle for me. After my appendix was removed I was diagnosed with endrometriosis. The specialist was recommending surgery but wanted to wait for my body to health from the other surgery so the doctors all agreed and said they would retest in 6 months. During that time I started taking I3C and have taking 4 pills a day. Just had the follow up test and the doctors were amazed. My lining went ftom 8 mil to 6 mil. Normal is 4 for my age of 66. They said I should keep taking it and we will retest in another 6 months. This pill has truly made a major difference in my life.
Sarah Pastian –
an amazing product
I’ve been using I3C caps for over 8 years. My situation is unique and am doing great…I was introduced to this product by Dr Marie Bell, my OBGYN. I will visit with anyone who might be skeptical. I’m 68 yrs old, and KNOW this product to have helped me alot.
Taz –
I started taking this back in 2007 for an abnormal Pap. My doctor at the time suggested this product and it cleared everything. I stopped taking it for a few years as all was fine. But just got the news that my old problems started again…so starting this protocol again. I love this.
Sylvia hairston (verified owner) –
Great product be using for at least 20years or more after first child. I was diagnosed with abnormal paps and was having to have more frequent paps done after 2years of no abnormal paps I have been back to a normal schedule with no abnormalities thanks to this product. Like all I was introduced by a Germany specialist when I was at the cancer center for the abnormal paps in the early 2000’s as this was just starting to utilized. She which I wish I knew whom she was stepped in after the doctor wanted to do laser (leap) removal of abnormal cells, thankful she did. She gave me the information to this site and I have been purchasing from them every since. Throughout my years I will stop taking but will restart after a month or 2 but has been on a positive journey with clear paps for over 20 years.