Description

Ultra-Pure Glutathione for Advanced Cellular Support

Reduced L-Glutathione Plus™ is formulated with Setria® USP-grade reduced L-glutathione and buffered with sodium bicarbonate to support stability, solubility, and versatility in use.

This advanced formula features a bioidentical, fermentation-derived glutathione designed for those seeking a high-purity, additive-free supplement. It contains no fillers, preservatives, excipients, dyes, flavors, or flow agents.

Reduced L-Glutathione Plus™ may be used in a variety of ways when appropriate, including oral or sublingual use, or prepared for other applications as directed by a qualified healthcare professional.

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Key Features

• Setria® USP-grade reduced L-glutathione
• Buffered with sodium bicarbonate for improved stability
• Fermentation-derived (non-animal source)
• Ultra-pure: no fillers or additives
• Non-GMO
• Made for versatile preparation and use
• Assembled in the USA under strict quality standards

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What Is Glutathione?

Glutathione is a naturally occurring tripeptide composed of three amino acids:
glutamic acid, cysteine, and glycine.

It is found in nearly every cell in the body, with higher concentrations in tissues such as the:

• Liver
• Lungs
• Brain
• Skin
• Eyes
• Gastrointestinal tract

Glutathione plays a role in cellular processes related to antioxidant activity and maintaining internal balance. It is often referred to as a central component of the body’s antioxidant network.

Levels of glutathione may decline over time and can be influenced by factors such as age, lifestyle, diet, and environmental exposure, leading to increased interest in supplemental forms.

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Why Setria® Glutathione Matters

Setria® is a patented, fermentation-derived form of reduced L-glutathione manufactured under tightly controlled conditions.

Key characteristics include:

• ≥98% purity (USP assay specification)
• Meets USP and Japanese Pharmacopeia (JP) standards
• Produced without animal-derived materials
• Vegetarian and allergen-free
• No added preservatives or stabilizers
• High consistency and quality control

Setria® glutathione has been widely studied for its role in supporting normal physiological processes related to antioxidant activity and cellular function.

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Buffered for Stability & Versatility

This formula includes sodium bicarbonate to help:

• Support pH balance and stability
• Improve mixability in solution
• Enhance versatility for different preparation methods

Buffering can help maintain glutathione integrity during preparation and use.

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Areas of Nutritional Interest

Reduced L-Glutathione Plus™ is commonly used in wellness routines focused on:

• Cellular antioxidant support
• Respiratory wellness routines
• Skin appearance and clarity
• Cognitive and neurological wellness
• General detox-focused wellness practices

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Additional Areas of Scientific Interest & Application

Glutathione has been studied for its involvement in a wide range of normal biological systems and processes, including:

• Brain, eye, and liver physiology
• Cytochrome P450 enzyme systems
• Metabolic conjugation pathways
• Methylation-related processes
• Cellular oxidative balance
• Immune system signaling pathways
• Thyroid-related physiological processes
• Response to lifestyle and environmental exposure factors

These areas reflect ongoing scientific interest in glutathione’s role in maintaining overall cellular and biochemical balance.

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When to Use / When Not to Use

When to Consider Use

Reduced L-Glutathione Plus™ may be considered as part of a wellness routine focused on:

• Supporting normal cellular antioxidant activity
• Maintaining overall cellular balance
• Supporting general wellness during periods of environmental or lifestyle-related stress
• Complementing nutrition and lifestyle practices that support metabolic and respiratory health

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When Not to Use (Important Considerations)

• Cancer Treatment Consideration
  Not recommended for individuals undergoing chemotherapy or radiation therapy, as glutathione may interact with certain treatment protocols. Similarly, products that may influence glutathione levels—such as N-acetylcysteine (NAC) or whey protein isolate—should be avoided during active treatment unless specifically directed by a qualified healthcare provider.
• Mold Exposure & Respiratory Consideration
  If you have been exposed to Stachybotrys chartarum (commonly referred to as black mold) and have a suspected or confirmed lung-related condition, aerosolized or nebulized use is not recommended unless under the care of a medical professional and following appropriate evaluation.

Oral use may still be considered in these situations, but only under the guidance of a qualified healthcare provider.

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General Guidance

• Consult a healthcare professional prior to use, especially if you have a medical condition or are under medical supervision
• Use only as directed
• Specialized preparation methods should only be performed when appropriate and guided by a professional

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How to Prepare

Mix fresh prior to use:

1. Open capsule(s) and empty contents into a clean container
2. Add distilled water or saline solution
3. Allow to dissolve until the solution is clear

Water-to-Capsule Ratio

• 1–3 capsules: 3 mL
• 4 capsules: 4 mL
• 5 capsules: 5 mL
• 6 capsules: 6 mL

Important:

• Use room temperature liquid only

• Do not use hot water (heat may degrade glutathione)

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Storage Guidelines

For optimal stability:

• Store at 68–72°F (20–22°C)
• Keep humidity below 50%
• Protect from heat, light, and moisture
• Do not freeze

High Humidity Tips

• Store bottle inside a sealed bag with a desiccant
• Avoid prolonged exposure to open air

High Heat / Refrigeration Guidance

• Refrigeration may be used in high-heat environments
• Always store bottle in a sealed bag with desiccant outside the bottle
• Prevent condensation exposure

Shelf Life

When stored properly, product stability is typically 3–5 years from manufacture date.

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Additional Product Notes

• Natural Odor: Glutathione may have a mild sulfur-like scent. This is normal.
• Oxidation: Product may gradually oxidize over time when exposed to air, heat, or humidity.
• Allergen Note: Glutathione is not a sulfite and is not associated with sulfite-related sensitivities.

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Frequently Asked Questions (FAQ)

Can you take Reduced L-Glutathione Plus™ orally?

Yes. Reduced L-Glutathione Plus™ can be taken orally. Glutathione is naturally present throughout the body, including within the gastrointestinal system, and plays a role in maintaining normal cellular and antioxidant processes. The gut, lungs, and brain are closely connected systems, and glutathione is involved in supporting overall cellular balance across these areas.

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Why choose Theranaturals Reduced L-Glutathione Plus™ over other brands?

Reduced L-Glutathione Plus™ is formulated with Setria® USP-grade glutathione, a high-purity, fermentation-derived ingredient manufactured to pharmacopeial standards.

This formula is designed for purity and simplicity:

• No fillers or excipients
• No preservatives or additives
• No flow agents or synthetic ingredients

You receive a clean, bioidentical form of glutathione with consistent quality and manufacturing standards.

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Is glutathione destroyed in the stomach or gut?

No. Reduced L-glutathione is not inherently destroyed during digestion. It can pass through the gastrointestinal environment and participate in normal physiological processes related to antioxidant activity and cellular balance.

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Is reduced L-glutathione the same as liposomal glutathione?

No. Reduced L-glutathione (GSH) is the natural, bioidentical form found in the body. Liposomal glutathione is encapsulated within lipid structures, which changes how it is processed.

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Can Reduced L-Glutathione Plus™ be used in nasal or other specialized preparations?

When properly prepared, it may be used in specialized applications under the guidance of a qualified healthcare professional. Always follow professional direction.

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Does glutathione support detox-related processes?

Glutathione is a central component of the body’s antioxidant network and is involved in normal biochemical processes that help maintain internal balance.

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Can you take too much glutathione?

Glutathione is naturally present in every cell and is required for normal cellular function. Individual needs may vary. Use as directed and consult a healthcare provider when needed.

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Can someone be allergic to glutathione?

Glutathione is a naturally occurring compound and is not classified as a sulfite. Individuals with sensitivities should consult a healthcare provider.

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What type of nebulizer is recommended?

For specialized applications, a nebulizer operating around ~16 psi (max ~32 psi ±5 psi) is commonly referenced. Avoid high-heat systems.

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Can glutathione be combined with colloidal silver?

Combination use should only be considered under the guidance of a qualified healthcare professional.

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Other Names

Gamma-Glutamylcysteinylglycine, Gamma-L-Glutamyl-L-Cysteinylglycine,
Gamma-L-Glutamyl-L-Cystéinylglycine, Glutathion, Glutatión,
L-Gamma-Glutamyl-L-Cysteinyl-Glycine, L-Gamma-Glutamyl-L-Cystéinyl-Glycine,
L-Glutathion, L-Glutathione, GSH,
N-(N-L-gamma-Glutamyl-L-cysteinyl)glycine, Setria®

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Supplement Disclaimer

This product is intended for supplemental use only. Use only as directed.

† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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References (Scientific Literature)

• PMCID: PMC2249747 (1)
• PMCID: PMC8078644
• PMCID: PMC7462336
• PMID: 23631796
• PMID: 11056412
• PMID: 10575337