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Cervical Dysplasia

 Can Indole-3-carbinol assist in disappearance of cervical dysplasia? Keri Marshall, ND, has written a review that gives several alternative ways of dealing with various degrees of cervical dysplasia including severe cervical dysplasia. Dr. Marshall states:

“Not all women with the virus (human papilloma virus, HPV) develop cervical dysplasia or cervical cancer. It has been postulated there are multiple host factors that contribute to progression of disease. Many of these factors, such as nutrient deficiencies can be reversed, which will result in regression of dysplastic lesions.”

Dr. Marshall asserts that cervical dysplasia is ideally suited to diet and supplement-related measures because of its well-established pre-invasive state. She points out the importance of women with cervical dysplasia eating fruits and vegetables which furnish substantial amounts of antioxidants and anticarcinogenic components.

One of the studies cited was done in Thailand where it was demonstrated that foods rich in vitamin A may reduce the progression of cervical dysplasia. Because of the known teratogenic side effects of vitamin A, there is limited application of this treatment for women with advanced cervical dysplasia.

Dr. Marshall states, “Although many studies suggest an association between decreased plasma beta carotene and the risk for cervical dysplasia, clinical trials examining the efficacy of beta carotene supplementation do not demonstrate a positive effect.”

On the other hand, dietary supplementation with dietary indoles including indole-3-carbinol (I3C) and diindolyl methane (DIM) are cited as ways of improving these conditions in women with cervical dysplasia. . Marshall cites the work of numerous investigators who have used tissue culture, animal, and human subjects with HPV-caused cervical dysplasia who have responded to treatment with I3C and DIM.

The link between folate deficiency and cervical dysplasia also receives attention. “Although laboratory findings support the role of folic acid in the cervical cancer continuum, clinical trials have not demonstrated positive results with this supplementation.”

Plasma levels of CoQ10 and alpha tocopherol have been found to be low in patients with cervical dysplasia. Levels of CoQ10 in cervicovaginal cells appear to be significantly lower in women diagnosed with cervical dysplasia. However, some studies have shown that a connection between lowered serum vitamin C and glutathione and cervical dysplasia were not statistically significant.

An escharotic treatment for cervical dysplasia is set forth in detail and a small clinical study was reported and received comment.

Marshall discusses the practical and the political problems involved with prevention of cervical dysplasia by a widespread vaccination program. One vaccination program and its outcome were discussed.

 This article by Dr. Marshall is a review of many approaches to the treatment of cervical dysplasia. Dr. Marshall does NOT in any way promote the use of I3C or any other dietary supplement.

“Cervical Dysplasia: Early Intervention,” Review by Keri Marshall, 2003, Alternative Medicine Review, 8 (2), 156-170

More info on the effects of indole-3-carbinol on cervical dysplasia.

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